What is computational and integrative biology? At a general level, computational biology is the study of biological systems using tools from traditional biomedical disciplines such as biology, chemistry and physics integrated with methods for analysis of interacting complex systems from mathematics and computer science. In particular, computational analysis is a prominent aspect of integrative biology, which analyzes a large number of interacting biological variables to obtain a fuller overall understanding of complex biological systems.

The goal of integrative biology is to extract broad quantitative organizational principles that can relate interactions of component parts to macroscopic behaviors of the complex system. Examples of areas of investigation particularly amenable to an integrative approach include ecological and physiological systems.

The Rutgers’ Center for Computational and Integrative Biology emphasizes the development of mathematical models for these biological systems, application of the models to data from laboratory and field investigations, the adjustment of the model based on its fit to and predictive value for experimental results and the subsequent modification of the experimental design based on the predictions of the model.

Research Directions

The CCIB is comprise of over 40 nationally and internationally recognized scholars and researchers, many of whom have received prestigious awards and honors. The CCIB regularly receives research funding from the National Science Foundation (NSF) and the National Institutes of Health (NIH). Some of the CCIB’s current research directions include:

  • Developmental Biology and Cell Signaling
  • Enhancer Analysis and Gene Regulatory Networks
  • Structural Modeling of Proteins
  • Biological Rhythms (circadian and ultradian)
  • Biofuels and sustainable energy
  • Predictive toxicology and pharmacology
  • Metagenomics
  • Movement of large groups and complex systems

The CCIB is always interested in exploring new research directions and is happy to lend its computational expertise to external collaborators. Please contact us if you are interested in discussing current or potential projects.

Opportunities for Support by CCIB 

>Faculty members of CCIB can apply for the Grant editing services to increase the quality of grant submission (more details in the link). CCIB supports Faculty Traveling based on matching funds to the CCIB Faculty Travel Grant.


>CCIB graduate students can apply for a Student Traveling Grant based on matching funds to the Dean’s Graduate Travel Grant >(use the Dean’s Traveling Grant Form to apply). All funding opportunities depend on budget availability. 


NSF Grant Awards

REU Site: Computational Biology Summer Research Experience at Rutgers-Camden  DBI-1559868
Benedetto Piccoli (PI), Joe Martin (Co-Principal Investigator)

MRI: Acquisition of a femtosecond laser system to enable multiphoton polymerization, photoporation, and laser ablation in liquids research
Award Number:1531783; Principal Investigator:Sean O’Malley; Co-Principal Investigator:Daniel Bubb, Eric Klein, George Kumi; Organization:Rutgers University Camden

CAREER: Composition, mechanical properties, and synthesis of the Caulobacter crescentus stalk
Award Number:1553004; Principal Investigator:Eric Klein; Co-Principal Investigator:; Organization:Rutgers University Camden

Computational and Experimental Systems Biology of Cyanobacterial Metabolism
Award Number:1515511; Principal Investigator:Desmond Lun; Co-Principal Investigator:G. Charles Dismukes; Organization:Rutgers University Camden

Best Practices on a Budget: Revamping Undergraduate Laboratory Sections to Stimulate Empirically-Based Learning and Foster Modern Research Skills
Award Number:1504881; Principal Investigator:Sean O’Malley; Co-Principal Investigator:Daniel Bubb, Grace Brannigan, Richard Jimenez; Organization:Rutgers University Camden;

RUI: Spectral Theory and Geometric Analysis in Several Complex Variables
Award Number:1500952; Principal Investigator:Siqi Fu;

ABI Innovation: Integrated Approach to Improve Detection of Genome Rearrangements
Award Number:1458202; Principal Investigator:Andrey Grigoriev;

RUI: Mechanisms of Modulation of GABA(A) receptors by Steroids and Lipophilic Hormones #1330728
Grace Brannigan (PI), Joseph V. Martin (co-PI)

CAREER: Dynamics and Diversity of Bone Morphogenetic Protein Signaling in Epithelial Cells #1149144
Nir Yakoby (PI)

MRI: Acquisition of a High-Performance Computing Cluster for the Interdisciplinary Research in Computational and Integrative Biology #1126052
Andrey Grigoriev (PI), Kwangwon Lee, Joe Martin, Michael Palis (Co-Principal Investigators)

Q-STEP: Community of Quantitative Scientists #0856435
Joe Martin (PI), Alex Roche; Daniel Bubb; Haydee Herrera (Co-Principal Investigators)

Mechanisms of Nanoparticle Generation by Laser Ablation of Thin Films in Liquids #1300920
Daniel Bubb (PI), Sean O’Malley (Co-Principal Investigator)

Transforming Potential into Promise: A Depth-First Approach   CCF-1433220
Rajiv Gandhi (PI)

Quantitative Trait Loci for Circadian Rhythm in Neurospora Crassa (Continuation)   MCB-0946860 2/2
Kwangwon Lee (PI)

REU site: Computational Biology Summer Program at Rutgers-Camden  DBI-1263163 1/3
Benedetto Piccoli (PI), Joe Martin (Co-Principal Investigator)

CPS: Synergy: Collaborative Research: Control of Vehicular Traffic Flow via Low Density Autonomous Vehicles  CNS-1446715
Benedetto Piccoli (PI)

Collaborative RUI: Quadrilateral Surface Meshes with Provable Quality Guarantees   CCF-1422004
Suneeta Ramaswami (PI)

NIH Grant Awards

Molecular Mechanishm of Natural Variation and Adaption of Circadian Clock  1R15GM117523-01
Kwangwon Lee (PI)

Area: Mechanisms Underlying Epithelial Cells’ Patterning and Morphogenesis 2R15GM101597-02
Nir Yakoby (PI)

Area: Mechanisms Underlying EGFR Signaling Distribution in Epithelial Tissues  1R15GM101597-01A1
Nir Yakoby (PI); Benedetto Piccoli (Co-PI)

Energy-based cold tolerance in genetically tractable eukaryotic systems 115GM093685-01R
Dan Shain (PI); Nir Yakoby (co-Principal Investigator)

AREA: Predictive Computational Acute Toxicity Modeling by Profiling Chemicals with Public Bioassay Data   1R15ES023148-01 1/1  
Hao Zhu (PI); 

Other Grant Awards

NJHF PC77-17 – 822243
Andrey Grigoriev (PI)

IRRI – Large Structural Variations in Rice Genomes – 439685 
Andrey Grigoriev (PI)

Optimization and Simulation Approaches – 439472
Benedetto Piccoli (PI)

Interaction of Inhaled Anesthetics with Macromolecules – 436642
Grace Brannigan (PI)

C/S Research Corp Effects of Chol & Lipid – 900042
Grace Brannigan (PI)

Research Corp Effects of Cholesterol & Lipid Sort – 438580
Grace Brannigan (PI)

C/S Research Corp Effects of Cholesterol & Lipid S – 220873
Grace Brannigan (PI)

US Army Research Office W911NF-141-0434 – 437233
Jinglin Fu (PI)

DURIP – Fluorescence Correlation Microcopy – 439444
Jinglin Fu (PI)

NJHF PC90-17 – 822251
Jongmin Nam (PI)

A Rutgers-Rowan Cross Collaboration Research Model – 439016
Joseph Martin (PI)

Science of Toxicology – 822290
Hao Zhu (PI)

Advance Predictive Modeling – 439473
Hao Zhu (PI)

Predictive Quantitative Structure Activity Relationship (QSAR) modeling of reproductive and developmental toxicity using integrated chemical and biological (HTS profiles) descriptors of molecules
Hao Zhu (PI)

Profiling chemicals based on public bioassay data for the development of predictive computational acute toxicity model
Hao Zhu (PI)

Establishing exclusion criteria  and the significance of inclusion:  Developing tools for the interpretation of complex DNA mixtures 4500001685 – 437782
Desmond Lun (PI)

Identification of gene networks:  An approach based on mathematical modeling
Desmond Lun (PI)

High-accuracy integration of transcriptomics and metabolic modeling with application to the metabolic engineering of Escherichia coli
Desmond Lun (PI)

Low-Template DNA Mixture Interpretation: Determining the Number of Contributors
Desmond Lun (PI)

Burroughs Welcome Fund – Fight Against Sleeping – 438579 
Simeon Kotchoni (PI)