The CCIB seminar series offers interesting presentations related to research in computational and integrative biology. The presentations reflect the types of collaborative research being done at the center and provide an opportunity to come together as a community for informal discussions and conversation.
Unless noted, all seminars take place during the free period (12:20pm – 1:20pm) in the Business and Science Building, Room 132.
Coffee and snacks are provided.
Tuesday, March 7, 2016 – BSB 132
Dr. Alicia Ebert, University of Vermont
TITLE: FGF8 signaling is required for proper vascularization of the zebrafish retina
ABSTRACT: Fibroblast growth factors (FGFs) are critical in many aspects of embryonic development and other cellular functions including apoptosis, cell adhesion, and proliferation. FGF8a, specifically, is known to work in coordination with FGF3 to initiate retinal ganglion cell (RGC) differentiation (Martinez-Morales et al., 2005). We identified FGF8a mRNA expression in the RGCs themselves a day after differentiation. Inhibition of FGF8 using the acerebellar (ace) mutant zebrafish, we show a decrease in retinal proliferation leading to smaller eyes. We also identified FGFR1b expression in the adjacent vascular tissue. Inhibiting FGFR1b with an antisense morpholino led to a phenocopy of FGF8 mutants. Loss of either the ligand (FGF8) or the receptor (FGFR1b) led to mispatterned retinal vasculature with decreases in blood flow through the eye. Our working model is that FGF8 secreted from the RGCs stimulates vascularization in the retina allowing for nutrient provisions to the developing nervous tissue. This neurovascular interaction is unique and has not been previously described in the retina.
SPRING 2016 Seminar Speakers
- March 22, 2016: Dr. Levine, Princeton
- March 29, 2016: Min Kyung Kim, CCIB Student
- April 5, 2016: Sean McQuade, CCIB Student
- April 12, 2016: Joe Kawash, CCIB Student
- April 19, 2016: Dr. William Saidel, Rutgers-Camden, Biology
- April 26, 2016: Dr. Grace Brannigan, Rutgers-Camden, Physics
- May 3, 2016: Reading Days
- May 10, 2016: Final Exams
Visit http://ccib.camden.rutgers.edu/seminars/past-seminars/ for a list of all past CCIB seminars.
CCIB Seminar Evaluation Form:
If you are a registered student for CCIB Seminar, you will need to complete a seminar evaluation form after each seminar.